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"Be joyful always; pray continually; give thanks in all circumstances, for this is God's will for you in Christ Jesus. " 1 Thessalonians 5: 18, NIV

While I was in the middle of cleani

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ng my kitchen floor this past week -I'm the kind who does this on my hands and knees with a cleaning rag - I was overcome with such immense gratitude for all God is and has done in my

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

life. Can you imagine that? Cleaning a floor and overcome with gratitude?

What happened was that I was listening to contemporary Christian music -it was either Third Day or Two Or Mor

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e - and it hit me! I was content and grateful that I had the use of arms and legs to be able to clean, that I had the energy to do the work, that I had a home I could clean, that I liv

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ed in a country where I had access to non-toxic cleaning products, the list became endless. I was even thanking God for being able to breathe. What an experience!

You see, for the las

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

t year nearly my husband and I have wanted to move to a new home, to have more. Here's what is hysterical and how wonderful our God is to always direct us to what is really important -

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

I lived in a home half-packed up to move but then we decided not to!

We'd had some trouble with this home last year and our initial response was to get the heck out of Dodge. That is

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

always our first reaction I think -to flee. Ask Jonah about that! The realization we came to was, we can have trouble anywhere anytime. Doesn't matter if you're in a multimillion dolla

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

r home or a a low-income home. Doesn't matter if you're rich or poor, young or old. We still have trouble.

The difference can be that when we put our full trust in God, obey Him and l

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ive for Him -breathe in Him continually, we do not have to worry or fret. We can be content with full gratitude to Him! That is what happened to me during a menial chore. I realized in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

that moment how grateful I was to God for ALL His provision. For Him. For my husband. For my dog. For our home.

We have started to unpack, put things back in order, get some upgradin

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

g done on the house, interacting with our neighbors again, cleaning out, fixing up, etc. I think that's what hit me so hard. We have community here. We have more than most folks in mos

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t countries can ever conceive of and yet our abundant material wealth in this country always has us seeking for more and better. My neighbor even said to me this morning while we were

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

both out planting plants, watering and doing general clean up, that she gets some new things and then a couple of months later the novelty has worn off.

That's how we are. As I was cl

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

eaning that floor (I'm pretty focused on having CLEAN) I realized how one day it would ALL be gone. That what matters is Jesus and our relationships with others! It's not like I didn't

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

GET that before, it's just that the whole idea hit me with such enormity that I could do nothing but literally fall down on my knees and give praise to our Sovereign God!

He allowed

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

me the cleansing of going through all the trials for nearly a year to get to this: Contentment in gratitude. This does not mean that I won't whine again in the future (human sinful nat

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ure), that I won't want anything else ever again, it just means that I finally was able to come to some understanding of what Paul said about being content -whether abased or abound be

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

content. Be grateful. Then realize, eternity in heaven with God and all my Christian brethren, is far far more than I could ever even conceive of wanting or needing. God is so generou

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s that He would do that for us through His only begotten Son. Amazing isn't it?

Be content my brothers and sisters and ever grateful to all our God is continually doing for and in us!

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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