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The truth revealed as we read about Hazael also reminds us of David who became so angry and indignant when he heard about the awful behaviors of a rich person described to him by Natha

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

n. Let me refresh your memory of the Biblical narrative.

The Lord directed Nathan to David at which time Nathan told him the following:

"There were two men in a certain to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n, one rich and the other poor. The rich man had a very large number of sheep and cattle, but the poor man had nothing except one little ewe lamb he had bought. He raised it, and it gr

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ew up with him and his children. It shared his food, drank from his cup and even slept in his arms. It was like a daughter to him.

Now a traveler came to the rich man, but the rich ma

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

refrained from taking one of his own sheep or cattle to prepare a meal for the traveler who had come to him. Instead, he took the ewe lamb that belonged to the poor man and prepared i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

t for the one who had come to him."

David burned with anger against the man and said to Nathan, "As surely as the Lord lives, the man who did this deserves to die! He must pay for tha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lamb four times over, because he did such a thing and had no pity.” Then Nathan said to David, "You are the man!...”

Heart-deception made David quick to condemn another

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

man's sinful deeds and be totally oblivious to his own. Heart-deception told David all was well when God was in actuality displeased with him. Heart-deception blinded David to the dig

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

essive state of his own character. Heart-deception so deadened David's soul that he did not realize God's Spirit had departed from him.

The heart is deceitful above all things and des

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

perately wicked. Who can know it?

Perhaps you have read or heard the legend told of a man who believed he was being pursued by a monster. His life was one catastrophe after another. F

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

re wood cut for the winter some how caught fire, the roof of his barn fell in, his cattle were dying and his land was eroding. The man believed the monster he would see in the dark eve

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ning shadows lived in a chasm near his farm and was responsible for his problems.

One night upon seeing the monster he cried out in anguish and attacked the form which in turn grabbed

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

him and they began to wrestle. It was a terrible fight. The man was knocked down many times but managed to rise each time and finally with a great rush of adrenaline he slammed the mon

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ster down to the ground pinning it down and griping its throat with his hands. Just as the man drew his knife and prepared to kill this dark, ominous creature, clouds which had hidden

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

full moon moved and allowed light to shine brightly and the man finally beheld the face of his adversary. The face of the monster was his own.

What lucidly emanates from Scripture is

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

that many of us, like David and Hazael, are not aware of the evil that lurks in our hearts. We do not want to admit, that at any given moment we are capable of committing the vilest o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

crimes. Yet, all around us are individuals who later, would not have believed they could have committed such horrendous acts. There are so many, many beacons who fell into evil, but w

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ho would not have thought it possible beforehand.

So what can be done about this seemingly undefeatable foe? What is the remedy? What is the cure? Is there any power to break the delu

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ion; to expel the poison and save the soul?

Of course. God in His loving kindness and mercy provided us with the cure. He sent us a heart specialist; an expert in cardiovascular disea

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

se. He is the balm in Gilead. He is the Lamb of God who takes away the sins of the world. His blood is our heart regulator. Nothing can save us from ourselves except the blood of Jesus

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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