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Many people ask me how dangerous are snakes?

The answer is that snakes have accumulated as many myths as sharks over the years. Like shark stories, most general beliefs about snakes have very little foundation in the tru

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

th.

However, they still remain animals that have developed unique ways of defending themselves and should be given the respect that they deserve.

Snakes are wild animals that just want to live out their lives the way th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ey were designed to. With the exceptions of a few species that live mainly in Australia and Africa, the vast majority of venomous snakes have absolutely no interest in humans and do not attack.

In fact, people who live i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

warmer climates have quite probably been within inches of a venomous snake and never known about it. Snakes will often give fair warning before striking by hissing or using their rattles. They do this because they do not

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

want to waste their venom on species that are not their prey.

Humans have a macabre relationship with snakes that is not really justified. The mere mention of the word initiates an anxious reaction that is deeply embedd

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d in our unconscious mind as a primeval defense strategy against unnecessary injury.

So what do you do if you or somebody else are bitten by a snake?

The first thing to do is to lie the person down and keep them still.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

That includes yourself if it is you who was bitten. By doing this we are trying to keep the pulse low. However this has limited effect because the anxiety one feels after snake bite raises the pulse. In saying that, runni

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

g about most definitely makes matters worse.

The second thing to do is to identify the type of snake that bit the person in question. If you can’t identify it make a mental note of exactly what it looked like.

Get some

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ice if possible and put it on the lesion. Keep the injured part of the body as still as possible. Apply a splint if you have suitable materials at hand.

Get medical help. Use your mobile phone to call an ambulance. If th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ambulance station is far from where you are, ask for a helicopter or failing that start to drive in the direction of the ambulance. mark your car in some way that the ambulance will recognize you. e.g. use a shirt as a f

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

lag. Call the police they may be closer to your area. If you are in a park or wilderness call the ranger service. They may keep anti venom.

Meet the ambulance half way and transfer the patient to the ambulance.

NEVER at

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tempt to suck the poison out or cut the wounded area. You may poison yourself and cause the venom to disperse more quickly. Only apply a tourniquet or any other type of blood flow restriction device if you are advised to

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

o so by a medical professional.

Facts about Bites:

Normally a snake will strike very quickly and will inject about 1/2 - 1/4 of a drop of venom from each fang. Venom takes time to mix with the blood. You can demonstrat

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e this by taking taking a glass of water and gently placing one drop of ink onto the surface of the water. You will notice how it takes a long time for the ink to mix throughout the water. Venom is the same. The venom is

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

omewhere embedded in the tissue. It needs some time for it to spread evenly throughout the body.

If you are going into a wilderness, let the authorities know where you are going and when you are expected back. Take distr

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ess flares with you and find out if you will have reception for your mobile phone. Find out where help stations are situated, including emergency telephones.

Wear sensible boots, Do not turn over logs and rocks. Do not s

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t down without first checking the area and especially do not lean on fallen trees or rocks without checking them well first.

Do not be tempted to touch wildlife including snakes. Give them a wide girth, keep clear. Do no

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t leave your boots outside of your tent at night, snakes like to crawl into places for protection from the cold.

Do not leave food scraps because they will attract the local rodents. Snakes follow their food source which

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is small animals, especially rodents. No rodents equals less chance of snakes.

If you don’t have a tent, sleep above ground in a hammock if you can. Follow these simple rules and your chances of being bitten are much les

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s.

Remember! of you are going to work in your garden or pick something up in a place that has good camouflage for snakes like under bushes, among leaves, rocks or timber test the whole area gently with a long stick first

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Letting you know what phone is better for reception and battery, plus letting you know what cell phone or provider you would like to go with

With the multiple types of depressive disorders that exist one must be aware that some kinds are almost warnings of other things to come.

A pet like a child is a great responsibility and the animal or bird is dependant on you to care for it and protect it. And if a move is stressful for children the pressure is ten –fold for a pet that cannot quite comprehend what is happening. Often a house filled with strangers, boxes, and din is not just frightening for a pet it can be quite intimidating.

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